Solutions

Personalized medicine

Our Bayesian, causal network based methodology exploits supercomputing technologies to integrate massive amounts of data and knowledge from different systems biology levels and clinical sources. This technology allows a unique pharmacogenomic analysis of the relevance of factors and their interaction for the process of a disease and its sequential treatment. Using a joint decision theoretic cost-utility analysis for efficacy and side-effects, this technology gives a new chance to save failed drugs by personalization and aids in the development of personalized niche-busters.

Causal model and interaction of genetic factors methotrexate treatment in leukemia.

Database (default)	0.032878 s
28.0156 kB
Benchmark	Min	Max	Average	Total
SHOW FULL COLUMNS FROM `languages` (1)	0.001687 s	0.001687 s	0.001687 s	0.001687 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `language`.* FROM `languages` AS `language` WHERE `url` = '' LIMIT 1 (1)	0.000669 s	0.000669 s	0.000669 s	0.000669 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `language`.* FROM `languages` AS `language` WHERE `id` = 1 LIMIT 1 (1)	0.000321 s	0.000321 s	0.000321 s	0.000321 s
0.7891 kB	0.7891 kB	0.7891 kB	0.7891 kB
SHOW FULL COLUMNS FROM `urls` (1)	0.001592 s	0.001592 s	0.001592 s	0.001592 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `url`.* FROM `urls` AS `url` (1)	0.000643 s	0.000643 s	0.000643 s	0.000643 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT * FROM `languages` (1)	0.000321 s	0.000321 s	0.000321 s	0.000321 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT * FROM `language_values` (1)	0.002207 s	0.002207 s	0.002207 s	0.002207 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SHOW FULL COLUMNS FROM `menu` (1)	0.001823 s	0.001823 s	0.001823 s	0.001823 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `menu`.* FROM `menu` AS `menu` JOIN `urls` ON (`urls`.`menu_id` = `menu`.`id`) JOIN `language_values` ON (`language_values`.`word_id` = `urls`.`route`) WHERE `language_values`.`value` = 'solutions/personalized_medicine' AND `language_values`.`language_id` = '1' LIMIT 1 (8)	0.000369 s	0.001415 s	0.000626 s	0.005009 s
0.6641 kB	0.6641 kB	0.6641 kB	5.3125 kB
SELECT `url`.* FROM `urls` AS `url` WHERE `route_name` = 'route_91' LIMIT 1 (1)	0.000779 s	0.000779 s	0.000779 s	0.000779 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SHOW FULL COLUMNS FROM `skeletons` (1)	0.001435 s	0.001435 s	0.001435 s	0.001435 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `skeleton`.* FROM `skeletons` AS `skeleton` WHERE `skeleton`.`id` = '2' LIMIT 1 (1)	0.000386 s	0.000386 s	0.000386 s	0.000386 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `portlets`.`name`, `url_portlets`.`id`, `url_portlets`.`container_id` FROM `url_portlets` JOIN `portlets` ON (`url_portlets`.`portlet_id` = `portlets`.`id`) WHERE `url_portlets`.`url_id` = '91' AND `url_portlets`.`container_id` IN ('1', '2', '3', '4', '5', '6') ORDER BY `url_portlets`.`ord` ASC (1)	0.001237 s	0.001237 s	0.001237 s	0.001237 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SHOW FULL COLUMNS FROM `url_portlets` (1)	0.001450 s	0.001450 s	0.001450 s	0.001450 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `urlportlet`.* FROM `url_portlets` AS `urlportlet` WHERE `urlportlet`.`id` = '582' LIMIT 1 (1)	0.000999 s	0.000999 s	0.000999 s	0.000999 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `urlportlet`.* FROM `url_portlets` AS `urlportlet` WHERE `urlportlet`.`id` = '580' LIMIT 1 (1)	0.000884 s	0.000884 s	0.000884 s	0.000884 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `menu`.* FROM `menu` AS `menu` JOIN `language_values` AS `ormlv0` ON (`ormlv0`.`word_id` = `menu`.`hidden`) WHERE `ormlv0`.`language_id` = '1' AND `ormlv0`.`value` = 0 AND `parent_id` = 0 ORDER BY `ord` ASC (1)	0.000702 s	0.000702 s	0.000702 s	0.000702 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `menu`.* FROM `menu` AS `menu` JOIN `language_values` AS `ormlv0` ON (`ormlv0`.`word_id` = `menu`.`hidden`) WHERE `ormlv0`.`language_id` = '1' AND `ormlv0`.`value` = '0' AND `parent_id` = '48' (1)	0.000614 s	0.000614 s	0.000614 s	0.000614 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `menu`.* FROM `menu` AS `menu` JOIN `language_values` AS `ormlv0` ON (`ormlv0`.`word_id` = `menu`.`hidden`) WHERE `ormlv0`.`language_id` = '1' AND `ormlv0`.`value` = '0' AND `parent_id` = '74' (1)	0.000628 s	0.000628 s	0.000628 s	0.000628 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `menu`.* FROM `menu` AS `menu` WHERE `menu`.`id` = '92' LIMIT 1 (5)	0.000407 s	0.000574 s	0.000479 s	0.002396 s
0.6641 kB	0.6641 kB	0.6641 kB	3.3203 kB
SELECT `menu`.* FROM `menu` AS `menu` JOIN `language_values` AS `ormlv0` ON (`ormlv0`.`word_id` = `menu`.`hidden`) WHERE `ormlv0`.`language_id` = '1' AND `ormlv0`.`value` = '0' AND `parent_id` = '90' (1)	0.000980 s	0.000980 s	0.000980 s	0.000980 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `menu`.* FROM `menu` AS `menu` JOIN `language_values` AS `ormlv0` ON (`ormlv0`.`word_id` = `menu`.`hidden`) WHERE `ormlv0`.`language_id` = '1' AND `ormlv0`.`value` = '0' AND `parent_id` = '91' (1)	0.000395 s	0.000395 s	0.000395 s	0.000395 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `menu`.* FROM `menu` AS `menu` JOIN `language_values` AS `ormlv0` ON (`ormlv0`.`word_id` = `menu`.`hidden`) WHERE `ormlv0`.`language_id` = '1' AND `ormlv0`.`value` = '0' AND `parent_id` = '92' (1)	0.000482 s	0.000482 s	0.000482 s	0.000482 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `urlportlet`.* FROM `url_portlets` AS `urlportlet` WHERE `urlportlet`.`id` = '584' LIMIT 1 (1)	0.000780 s	0.000780 s	0.000780 s	0.000780 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `urlportlet`.* FROM `url_portlets` AS `urlportlet` WHERE `urlportlet`.`id` = '579' LIMIT 1 (1)	0.000793 s	0.000793 s	0.000793 s	0.000793 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `urlportlet`.* FROM `url_portlets` AS `urlportlet` WHERE `urlportlet`.`id` = '581' LIMIT 1 (1)	0.000757 s	0.000757 s	0.000757 s	0.000757 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `menu`.* FROM `menu` AS `menu` JOIN `language_values` AS `ormlv0` ON (`ormlv0`.`word_id` = `menu`.`hidden`) WHERE `ormlv0`.`language_id` = '1' AND `ormlv0`.`value` = '0' AND `parent_id` = 0 ORDER BY `ord` ASC (1)	0.000516 s	0.000516 s	0.000516 s	0.000516 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `menu`.* FROM `menu` AS `menu` WHERE `menu`.`parent_id` = '92' (1)	0.000446 s	0.000446 s	0.000446 s	0.000446 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `urlportlet`.* FROM `url_portlets` AS `urlportlet` WHERE `urlportlet`.`id` = '583' LIMIT 1 (1)	0.000672 s	0.000672 s	0.000672 s	0.000672 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `url_id` FROM `url_portlets` WHERE `id` = '583' (1)	0.000624 s	0.000624 s	0.000624 s	0.000624 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB
SELECT `menu_id` FROM `urls` WHERE `id` = '91' (1)	0.000651 s	0.000651 s	0.000651 s	0.000651 s
0.6641 kB	0.6641 kB	0.6641 kB	0.6641 kB

Database (default)

0.032878 s

28.0156 kB

Benchmark

Min

Max

Average

Total

SHOW FULL COLUMNS FROM `languages` (1)

0.001687 s

0.6641 kB

SELECT `language`.* FROM `languages` AS `language` WHERE `url` = '' LIMIT 1 (1)

0.000669 s

0.6641 kB

SELECT `language`.* FROM `languages` AS `language` WHERE `id` = 1 LIMIT 1 (1)

0.000321 s

0.7891 kB

SHOW FULL COLUMNS FROM `urls` (1)

0.001592 s

0.6641 kB

SELECT `url`.* FROM `urls` AS `url` (1)

0.000643 s

0.6641 kB

SELECT * FROM `languages` (1)

0.000321 s

0.6641 kB

SELECT * FROM `language_values` (1)

0.002207 s

0.6641 kB

SHOW FULL COLUMNS FROM `menu` (1)

0.001823 s

0.6641 kB

SELECT `menu`.* FROM `menu` AS `menu` JOIN `urls` ON (`urls`.`menu_id` = `menu`.`id`) JOIN `language_values` ON (`language_values`.`word_id` = `urls`.`route`) WHERE `language_values`.`value` = 'solutions/personalized_medicine' AND `language_values`.`language_id` = '1' LIMIT 1 (8)

0.000369 s

0.001415 s

0.000626 s

0.005009 s

0.6641 kB

5.3125 kB

SELECT `url`.* FROM `urls` AS `url` WHERE `route_name` = 'route_91' LIMIT 1 (1)

0.000779 s

0.6641 kB

SHOW FULL COLUMNS FROM `skeletons` (1)

0.001435 s

0.6641 kB

SELECT `skeleton`.* FROM `skeletons` AS `skeleton` WHERE `skeleton`.`id` = '2' LIMIT 1 (1)

0.000386 s

0.6641 kB

SELECT `portlets`.`name`, `url_portlets`.`id`, `url_portlets`.`container_id` FROM `url_portlets` JOIN `portlets` ON (`url_portlets`.`portlet_id` = `portlets`.`id`) WHERE `url_portlets`.`url_id` = '91' AND `url_portlets`.`container_id` IN ('1', '2', '3', '4', '5', '6') ORDER BY `url_portlets`.`ord` ASC (1)

0.001237 s

0.6641 kB

SHOW FULL COLUMNS FROM `url_portlets` (1)

0.001450 s

0.6641 kB

SELECT `urlportlet`.* FROM `url_portlets` AS `urlportlet` WHERE `urlportlet`.`id` = '582' LIMIT 1 (1)

0.000999 s

0.6641 kB

SELECT `urlportlet`.* FROM `url_portlets` AS `urlportlet` WHERE `urlportlet`.`id` = '580' LIMIT 1 (1)

0.000884 s

0.6641 kB

SELECT `menu`.* FROM `menu` AS `menu` JOIN `language_values` AS `ormlv0` ON (`ormlv0`.`word_id` = `menu`.`hidden`) WHERE `ormlv0`.`language_id` = '1' AND `ormlv0`.`value` = 0 AND `parent_id` = 0 ORDER BY `ord` ASC (1)

0.000702 s

0.6641 kB

0.000614 s

0.6641 kB

0.000628 s

0.6641 kB

SELECT `menu`.* FROM `menu` AS `menu` WHERE `menu`.`id` = '92' LIMIT 1 (5)

0.000407 s

0.000574 s

0.000479 s

0.002396 s

0.6641 kB

3.3203 kB

0.000980 s

0.6641 kB

0.000395 s

0.6641 kB

0.000482 s

0.6641 kB

SELECT `urlportlet`.* FROM `url_portlets` AS `urlportlet` WHERE `urlportlet`.`id` = '584' LIMIT 1 (1)

0.000780 s

0.6641 kB

SELECT `urlportlet`.* FROM `url_portlets` AS `urlportlet` WHERE `urlportlet`.`id` = '579' LIMIT 1 (1)

0.000793 s

0.6641 kB

SELECT `urlportlet`.* FROM `url_portlets` AS `urlportlet` WHERE `urlportlet`.`id` = '581' LIMIT 1 (1)

0.000757 s

0.6641 kB

0.000516 s

0.6641 kB

SELECT `menu`.* FROM `menu` AS `menu` WHERE `menu`.`parent_id` = '92' (1)

0.000446 s

0.6641 kB

SELECT `urlportlet`.* FROM `url_portlets` AS `urlportlet` WHERE `urlportlet`.`id` = '583' LIMIT 1 (1)

0.000672 s

0.6641 kB

SELECT `url_id` FROM `url_portlets` WHERE `id` = '583' (1)

0.000624 s

0.6641 kB

SELECT `menu_id` FROM `urls` WHERE `id` = '91' (1)

0.000651 s

0.6641 kB

Kohana	0.003877 s
54.2656 kB
Benchmark	Min	Max	Average	Total
find_file (77)	0.000016 s	0.000128 s	0.000050 s	0.003877 s
0.5078 kB	2.1328 kB	0.7047 kB	54.2656 kB

Kohana

0.003877 s

54.2656 kB

Benchmark

Min

Max

Average

Total

find_file (77)

0.000016 s

0.000128 s

0.000050 s

0.003877 s

0.5078 kB

2.1328 kB

0.7047 kB

54.2656 kB

Requests	0.096182 s
1,922.3906 kB
Benchmark	Min	Max	Average	Total
"solutions/personalized_medicine" (1)	0.065855 s	0.065855 s	0.065855 s	0.065855 s
1,451.3281 kB	1,451.3281 kB	1,451.3281 kB	1,451.3281 kB
"en/portlet/content" « "solutions/personalized_medicine" (1)	0.005272 s	0.005272 s	0.005272 s	0.005272 s
232.6016 kB	232.6016 kB	232.6016 kB	232.6016 kB
"en/portlet/menu" « "solutions/personalized_medicine" (1)	0.009921 s	0.009921 s	0.009921 s	0.009921 s
59.6484 kB	59.6484 kB	59.6484 kB	59.6484 kB
"en/portlet/footer" « "solutions/personalized_medicine" (1)	0.001462 s	0.001462 s	0.001462 s	0.001462 s
20.5000 kB	20.5000 kB	20.5000 kB	20.5000 kB
"en/portlet/contentheader" « "solutions/personalized_medicine" (1)	0.003057 s	0.003057 s	0.003057 s	0.003057 s
45.9688 kB	45.9688 kB	45.9688 kB	45.9688 kB
"en/portlet/contentmenu" « "solutions/personalized_medicine" (1)	0.007731 s	0.007731 s	0.007731 s	0.007731 s
55.9844 kB	55.9844 kB	55.9844 kB	55.9844 kB
"en/portlet/contentimage" « "solutions/personalized_medicine" (1)	0.004906 s	0.004906 s	0.004906 s	0.004906 s
54.6641 kB	54.6641 kB	54.6641 kB	54.6641 kB

Requests

0.096182 s

1,922.3906 kB

Benchmark

Min

Max

Average

Total

"solutions/personalized_medicine" (1)

0.065855 s

1,451.3281 kB

"en/portlet/content" « "solutions/personalized_medicine" (1)

0.005272 s

232.6016 kB

"en/portlet/menu" « "solutions/personalized_medicine" (1)

0.009921 s

59.6484 kB

"en/portlet/footer" « "solutions/personalized_medicine" (1)

0.001462 s

20.5000 kB

"en/portlet/contentheader" « "solutions/personalized_medicine" (1)

0.003057 s

45.9688 kB

"en/portlet/contentmenu" « "solutions/personalized_medicine" (1)

0.007731 s

55.9844 kB

"en/portlet/contentimage" « "solutions/personalized_medicine" (1)

0.004906 s

54.6641 kB

Application Execution (278)	0.083565 s	0.615440 s	0.188424 s	0.111667 s
4,653.4688 kB	5,250.6641 kB	4,745.3488 kB	4,707.4766 kB

Application Execution (278)

0.083565 s

0.615440 s

0.188424 s

0.111667 s

4,653.4688 kB

5,250.6641 kB

4,745.3488 kB

4,707.4766 kB